Immunohistochemical Expression of Epithelial Mesenchymal Transition Proteins in Squamous Cell Carcinoma of the Oral Cavity

Background & Objective: Epithelial-Mesenchymal transition (EMT) is known to be a possible mechanism in tumor progression; however, there insufficient evidence support the contribution of this process human cancers. The present study aimed evaluate expression EMT markers normal oral epithelium and squamous cell carcinoma also correlates with some clinicopathological parameters.Methods: This was conducted on 70 samples, including 20 cases 50 Oral Squamous Carcinoma (OSCC). To examine level these proteins, immunohistochemical staining performed for samples using E-cadherin N-cadherin monoclonal antibodies.Results: Reduced observed 74% OSCC 15% samples; difference statistically significant (P˂0.000). With progression SCC from well towards poor differentiation, decreased; not (P=0.642). Normal epithelial specimens were negative 75% cases, whereas showed high 46% (P=0.01). Although 62.5% poorly differentiated N-cadherin, between histopathological grades (P=0.586). No relationship found patient’s age, gender, location.Conclusion: that tissues phenotype (reduced N-cadherin) compared mucosa which may indicate key role during carcinogenesis.